FCMS(111Validation) Phase 2

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Buyers

Value

£100,000

Suppliers

Classifications

  • Medical analysis services

Tags

  • award
  • contract

Published

11 months ago

Description

NHS 111 enhanced services to assist patients and ensure accurate prioritisation .

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  • Contract Agreement

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  • Award Notice

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Long Read Sequencing - Babies in Focus

Genomics England is procuring long-read whole genome sequencing services. In partnership with the NHS and other stakeholders, we are co-designing and delivering a national research study, the Generation Study, involving up to 100,000 newborns to understand the role of whole genome sequencing to achieve more timely diagnosis of rare conditions and access to early intervention, enabling faster and better care for babies born with rare childhood onset diseases. The Generation Study aims to assess the benefits, challenges, and feasibility of integrating whole genome sequencing into newborn screening to enhance the early diagnosis and treatment of rare genetic conditions. If successful, the study could establish the foundation for the world's first national newborn screening program incorporating whole genome sequencing. The study also aims to understand how, with consent, newborns' genomic and health data could be used for research to enable new diagnostic discoveries and treatments to be developed. As part of the consent to the study mothers are asked for permission to retain the baby's data and sample and link it to clinical data over the course of their life and the ability to recontact them with further research opportunities. The study will provide an invaluable dataset to researchers across industry and academia, and we have the opportunity to conduct further studies in a subset of these families to maximise the future impact to patients, researchers and the NHS. Deepening our dataset, including by introducing new modalities, is a priority for industry. To do this, we to plan to develop an enhanced longitudinal birth cohort (Babies in Focus) in a subset of participants in the next five years. This will begin with conducting long-read whole genome sequencing for at least 2,000 samples across two long-read technologies. This will help inform us of the plans for the larger funding that is being requested as part of the 2026-2030 spending review. These services will be split into two lots: Lot 1: 1,000 samples to be delivered to the supplier and sequenced between 5 January 2026 and 31 March 2026. An earlier start date may be mutually agreed by the Supplier and the Authority if implementation is completed before 5 January 2026. This lot has an estimated value of £1.4M. Lot 2: 1,000 samples to be delivered and sequenced between 1 April 2026 and 1 September 2026. An earlier start date may be mutually agreed by Supplier and the Authority, subject to the Supplier's willingness and capability, and Authority funding. This lot has an estimated value of £1.4M There is an optional extension (volume to be confirmed) of up to a total of 1,000 additional samples, valued at £1.4M. These optional extension volumes may be awarded to one or split across both lots. These optional volumes must be delivered by 1 March 2027.

Katy Reed

Katy Reed

Published 1 week ago

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Organisation

NHS South Yorkshire Integrated Care Board

Body governed by public law

+44 7915902897

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