Dianthus Nano System

Description

VEAT NOTICE 
The University has a requirement to purchase an instrument that features the latest innovation for characterising biomolecular binding affinities. 

The University has published this VEAT notice and intends to award a contract to NanoTemper Technologies GmbH following the expiry of 10 days from the date of publication of this notice.

Additional information: The works, supplies or services can be provided only by a particular economic operator for the following reason: 

absence of competition for technical reasons

Explanation: Specific features of the system include the

• Measurements are performed in solution (i.e. no immobilisation is required)
• Capability to quantify interactions in complex solutions (crude extract, serum)
• Means to determine binding constant over a wide range (5 nM - high millimolar) as well as stoichiometry and thermodynamic parameters
• Power to work at low nanomolar concentrations
• Advantage of small sample volumes (20 microliter) coupled with the capacity to run samples in high-throughput mode using standard 384 well-plate
• Used detection modalities based on two techniques: Spectral shift detection and Temperature-Related Intensity Change (TRIC)
• Microfluidics-free
• Mass independent measurement i.e., the measurable molecular weight range is from 101-107 Da
• Measure up to 384 datapoints per run 
• Advantage of small sample volumes (20 microliter) coupled with the capacity to run samples in high-throughput mode using standard SBS 384 well-plate format